In early 2016, Ozuna rose to prominence for his appearance in the single “La Ocasión”, a collaboration with DJ Luian, Mambo Kingz, De La Ghetto, Arcángel, and Anuel AA. The single reached number 22 on the Billboard Hot Latin Songs chart. In March, Ozuna released a remix of his song “No Quiere Enamorarse”, featuring Daddy Yankee. In September, he released his most popular single at the time, “Dile Que Tu Me Quieres”, which earned him a place at number 13 on the Billboard Latin chart at the end of the year. Ozuna also had two other songs that made it on the ranking, “Si Tu Marido No Te Quiere (Remix)” (featuring Arcángel and Farruko) and “En La Intimidad”, which reached the top 30.
In June 2017, VP Entertainment/Dimelo Vice president, Vicente Saavedra, signed an agreement with Sony Music Latin. The deal included distribution for all artists represented by Saavedra agencies, starting with Ozuna’s first studio album, Odisea. It was released on August 11. The Odisea tour began on May 26, 2017, in Atlanta, and included over 25 cities, among them, Chicago, Miami, Houston, and Los Angeles. Eventually, it was renamed the Odisea World Tour, with Ozuna visiting European cities and Latin America.
The single “Te Vas” reached more than 710 million views on YouTube, making it Ozuna’s most played song on the website. Achieving success in the Latin market made many important figures in the genre consider Ozuna to be one of the best artists and the most successful of the new generation of reggaeton artists.
In 2017, Ozuna released many singles, including “Dile Que Tu Me Quieres (Remix)” (featuring Yandel), “Después de las 12” and, in April of that year, “Tu Foto”, which reached the 10th spot on the Latin Billboard list, and reached more than 780 million views on YouTube. He also released several collaborations, including “La Rompe Corazones” (featuring Daddy Yankee), “Escápate Conmigo” (featuring Wisin), “Ahora Dice” (with J Balvin, Arcángel, and Chris Jeday) among others. “Se Preparó” was released on August 10, 2017, and, as of October 2019, has more than 1.2 billion views on YouTube.
Odisea spent over 30 weeks at number one on the Billboard Top Latin Albums chart, surpassing the 29-week record held by Luis Miguel’s Segundo Romance as the longest-charting number one album by a male artist.